Article
Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations.
Cancer research - 1 Apr 2017
Blaj Cristina, Schmidt Eva Marina, Lamprecht Sebastian, Hermeking Heiko, Jung Andreas, Kirchner Thomas, Horst David
Abstract excerpt
About 40% of colorectal cancers have mutations in KRAS accompanied by downstream activation of MAPK signaling, which promotes tumor invasion and progression. Here, we report that MAPK signaling shows strong intratumoral heterogeneity and unexpectedly remains regulated in colorectal cancer irrespective of KRAS mutation status. Using primary colorectal cancer tissues, xenograft models, and MAPK reporter constructs,...
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