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Article

Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.

Molecular & cellular proteomics : MCP - 1 Feb 2013

Demory Beckler Michelle, Higginbotham James N, Franklin Jeffrey L, Ham Amy-Joan, Halvey Patrick J, Imasuen Imade E, Whitwell Corbin, Li Ming, Liebler Daniel C, Coffey Robert J

Abstract excerpt

Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of mutant KRAS are less understood. We recently reported that exosomes isolated from mutant KRAS-expressing colon cancer cells enhanced the invasiveness of recipient cells relative to exosomes purified from wild-type KRAS-expressing...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23161513
DOI: 10.1074/mcp.M112.022806
PMCID: PMC3567858

Genes

KRAS
DLD
EGFR
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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