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Article

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.

Nature cell biology - 1 Jun 2024

Xin Tianchi, Gallini Sara, Wei Haoyang, Gonzalez David G, Matte-Martone Catherine, Machida Hiroki, Fujiwara Hironobu, Pasolli H Amalia, Suozzi Kathleen C, Gonzalez Lauren E, Regot Sergi, Greco Valentina

Abstract excerpt

Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to cancer. However, it is largely unclear how oncogenes perturb stem cells' orchestration to disrupt tissue. Here we used intravital imaging to investigate the mechanisms by which oncogenic Kras mutation causes tissue disruption in the hair follicle. Through...

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Identifiers

PMID: 38689013
DOI: 10.1038/s41556-024-01413-y
PMCID: PMC11519783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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