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Article

Nano-scale physical properties characteristic to metastatic intestinal cancer cells identified by high-speed scanning ion conductance microscope.

Biomaterials - 1 Jan 2022

Wang Dong, Sun Linhao, Okuda Satoru, Yamamoto Daisuke, Nakayama Mizuho, Oshima Hiroko, Saito Hideyuki, Kouyama Yuta, Mimori Koshi, Ando Toshio, Watanabe Shinji, Oshima Masanobu

Abstract excerpt

Recent genetic studies have indicated relationships between gene mutations and colon cancer phenotypes. However, how physical properties of tumor cells are changed by genetic alterations has not been elucidated. We examined genotype-defined mouse intestinal tumor-derived cells using a high-speed scanning ion conductance microscope (HS-SICM) that can obtain high-resolution live images of nano-scale topography and...

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PMID: 34794825
DOI: 10.1016/j.biomaterials.2021.121256

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