Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.

Journal of the National Cancer Institute - 1 Feb 2014

Moon Byoung-San, Jeong Woo-Jeong, Park Jieun, Kim Tae Il, Min Do Sik, Choi Kang-Yell

Abstract excerpt

BACKGROUND: Adenomatous polyposis coli (APC) loss-of-function mutations and K-Ras gain-of-function mutations are common abnormalities that occur during the initiation and intermediate adenoma stages of colorectal tumorigenesis, respectively. However, little is known about the role these mutations play in cancer stem cells (CSCs) associated with colorectal cancer (CRC) tumorigenesis. METHODS: We analyzed tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AC133 Antigen
Share to Adenomatous Polyposis Coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenomatous Polyposis Coli Protein

Share to Cell Adhesion Molecules, Neuronal

Share to Fetal Proteins

Share to Heterografts

Share to Hyaluronan Receptors

Share to Wnt Proteins

Source

Identifiers

PMID: 24491301
DOI: 10.1093/jnci/djt373

Genes

DLD
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.PMID 24491301Read ↗

Wnt signaling in cancer stem cells and colon cancer metastasisSemantic proximity Read ↗

A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signalingSemantic proximity Read ↗

A Destabilizer of Both Wnt/β-Catenin and Ras/ERK Pathways Suppresses Cancer Stem Cell Activation in Colorectal CancerSemantic proximity Read ↗

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.Semantic proximity Read ↗

Signaling in colon cancer stem cellsSemantic proximity Read ↗

Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response.Semantic proximity Read ↗

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.Semantic proximity Read ↗

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancerSemantic proximity Read ↗

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheresSemantic proximity Read ↗

Wnt signaling in adult intestinal stem cells and cancerSemantic proximity Read ↗

Wnt and BMP signals control intestinal adenoma cell fates.Semantic proximity Read ↗

Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.