CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism.

doi:10.1126/scisignal.adl5100

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Article

CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism.

Science signaling - 29 Oct 2024

Rondeau Vincent, Kalogeraki Maria, Roland Lilian, Nader Zeina Abou, Gourhand Vanessa, Bonaud Amélie, Lemos Julia, Khamyath Mélanie, Moulin Clémentine, Schell Bérénice, Delord Marc, Bidaut Ghislain, Lecourt Séverine, Freitas Christelle, Anginot Adrienne, Mazure Nathalie, McDermott David H, Parietti Véronique, Setterblad Niclas, Dulphy Nicolas, Bachelerie Françoise, Aurrand-Lions Michel, Stockholm Daniel, Lobry Camille, Murphy Philip M, Espéli Marion, Mancini Stéphane J C, Balabanian Karl

Abstract excerpt

Both cell-intrinsic and niche-derived, cell-extrinsic cues drive the specification of hematopoietic multipotent progenitors (MPPs) in the bone marrow, which comprise multipotent MPP1 cells and lineage-restricted MPP2, MPP3, and MPP4 subsets. Patients with WHIM syndrome, a rare congenital immunodeficiency caused by mutations that prevent desensitization of the chemokine receptor CXCR4, have an excess of myeloid...

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PMID: 39471249
DOI: 10.1126/scisignal.adl5100

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