Article

CXCR4 antagonism restores dendritic cell migration and activation in a WHIM syndrome mouse model

2026-05-13

Abstract excerpt

WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a primary immunodeficiency caused by gain-of-function in CXCR4 chemokine receptor (CXCR4 GOF ) in response to its chemokine ligand CXCL12. The patients suffering from this syndrome display lymphopenia and neutropenia, and most of them show exacerbated susceptibility to human papillomavirus pathogenesis. In a mouse model harboring a WHI...

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Literature Corpus work: 072db241-2191-5a28-9d01-5482e649934e
DOI: 10.64898/2026.05.10.724115

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