Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VEGF-C protects the integrity of the bone marrow perivascular niche in mice

25 Aug 2020

Abstract excerpt

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory signals. Radiation and chemotherapy disrupt the HSC niche, including its sinusoidal vessels and perivascular cells, contributing to delayed hematopoietic recovery. Thus, identification of factors that can protect the HSC niche during an injury could offer a significant therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Lymphatic System and Diseases
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32842144
DOI: 10.1182/blood.2020005699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VEGF-C protects the integrity of the bone marrow perivascular niche in micePMID 32842144Read ↗

JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury.Semantic proximity Read ↗

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative HematopoiesisSemantic proximity Read ↗

Concise Review: Paracrine Functions of Vascular Niche Cells in Regulating Hematopoietic Stem Cell Fate.Semantic proximity Read ↗

Hematopoiesis and microenvironment in hematological malignanciesSemantic proximity Read ↗

Endothelial and perivascular cells maintain haematopoietic stem cells.Semantic proximity Read ↗

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndromeSemantic proximity Read ↗

Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and AgingSemantic proximity Read ↗

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGFSemantic proximity Read ↗

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche.Semantic proximity Read ↗

The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapySemantic proximity Read ↗

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.Semantic proximity Read ↗

The Bone Marrow Pericyte: An Orchestrator Of Vascular NicheSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.