Article
Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.
Blood - 14 Jun 2012
Balabanian Karl, Brotin Emilie, Biajoux Vincent, Bouchet-Delbos Laurence, Lainey Elodie, Fenneteau Odile, Bonnet Dominique, Fiette Laurence, Emilie Dominique, Bachelerie Françoise
Abstract excerpt
Desensitization controls G protein-dependent signaling of chemokine receptors. We investigate the physiologic implication of this process for CXCR4 in a mouse model harboring a heterozygous mutation of the Cxcr4 gene, which engenders a desensitization-resistant receptor. Such anomaly is linked to the warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, a human rare combined immunodeficiency....
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