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Article

Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization.

The Journal of experimental medicine - 3 Jul 2017

Freitas Christelle, Wittner Monika, Nguyen Julie, Rondeau Vincent, Biajoux Vincent, Aknin Marie-Laure, Gaudin Françoise, Beaussant-Cohen Sarah, Bertrand Yves, Bellanné-Chantelot Christine, Donadieu Jean, Bachelerie Françoise, Espéli Marion, Dalloul Ali, Louache Fawzia, Balabanian Karl

Abstract excerpt

The CXCL12/CXCR4 signaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention and quiescence in bone marrow. Gain-of-function CXCR4 mutations that affect homologous desensitization of the receptor have been reported in the WHIM Syndrome (WS), a rare immunodeficiency characterized by lymphopenia. The mechanisms underpinning this remain obscure. Using a mouse model with a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28550161
DOI: 10.1084/jem.20160806
PMCID: PMC5502422

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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