Article

CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanisms

2023-06-01

Abstract excerpt

<h4>ABSTRACT</h4> How cell-extrinsic niche-related and cell-intrinsic cues drive lineage specification of hematopoietic multipotent progenitors (MPPs) in the bone marrow (BM) is partly understood. We show that CXCR4 signaling strength regulates localization and fate of MPPs. In mice phenocopying the BM myeloid skewing of patients with WHIM Syndrome (WS), a rare immunodeficiency caused by gain-of-function CXCR4 m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edd06244-df52-552b-bd0b-599c1c6aab53
DOI: 10.1101/2023.05.31.542899

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanismsDOI 10.1101/2023.05.31.542899Read

CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism.Semantic proximity Read

WHIM Syndrome-linked CXCR4 mutations drive osteoporosis by mitigating the osteogenic specification of skeletal stromal cellsSemantic proximity Read

WHIM Syndrome-linked CXCR4 mutations drive osteoporosis.Semantic proximity Read

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.Semantic proximity Read

Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization.Semantic proximity Read

Vhl deletion in <i>Dmp1</i> -expressing cells alters MEP metabolism and promotes stress erythropoiesisSemantic proximity Read

CXCR4 signaling in health and disease.Semantic proximity Read

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.Semantic proximity Read

Aberrant CXCR4 Signaling at Crossroad of WHIM Syndrome and Waldenstrom's Macroglobulinemia.Semantic proximity Read

Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric miceSemantic proximity Read

WHIM syndrome: A defect in CXCR4 signalingSemantic proximity Read

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesisSemantic proximity Read