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Article

Reporter Alleles in hiPSCs: Visual Cues on Development and Disease.

International journal of molecular sciences - 13 Oct 2024

Cotta Gustavo Caldeira, Teixeira Dos Santos Rachel Castro, Costa Guilherme Mattos Jardim, Lacerda Samyra Maria Dos Santos Nassif

Abstract excerpt

Reporter alleles are essential for advancing research with human induced pluripotent stem cells (hiPSCs), notably in developmental biology and disease modeling. This study investigates the state-of-the-art gene-editing techniques tailored for generating reporter alleles in hiPSCs, emphasizing their effectiveness in investigating cellular dynamics and disease mechanisms. Various methodologies, including the...

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Identifiers

PMID: 39456792
DOI: 10.3390/ijms252011009
PMCID: PMC11507014

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