Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Editing the genome of hiPSC with CRISPR/Cas9: disease models.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2017

Bassett Andrew R

Abstract excerpt

The advent of human-induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible. Combining this with recent advances in genome editing techniques such as the clustered regularly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Disease Models, Animal
Share to Gene Editing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Engineering

Share to Genetic Variation

Share to Genome

Share to Induced Pluripotent Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 28303292
DOI: 10.1007/s00335-017-9684-9
PMCID: PMC5569153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Editing the genome of hiPSC with CRISPR/Cas9: disease models.PMID 28303292Read ↗

CRISPR‐Cas9‐Based Genome Editing of Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Genomic Editing Tools to Model Human Diseases with Isogenic Pluripotent Stem CellsSemantic proximity Read ↗

CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Toward a CRISPR Picture: Use of CRISPR/Cas9 to Model Diseases in Human Stem Cells In Vitro.Semantic proximity Read ↗

Precision genome-editing with CRISPR/Cas9 in human induced pluripotent stem cellsSemantic proximity Read ↗

Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.Semantic proximity Read ↗

Investigating human disease using stem cell models.Semantic proximity Read ↗

Generation and characterization of three CRISPR/Cas9 edited RB1 null hiPSC lines for retinoblastoma disease modelling.Semantic proximity Read ↗

Recent advances in human stem cell-based modeling of Tuberous Sclerosis ComplexSemantic proximity Read ↗

Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology.Semantic proximity Read ↗

Generation and genetic repair of two human induced pluripotent stem cell lines from patients with Epidermolysis Bullosa simplex associated with a heterozygous mutation in the translation initiation codon of KLHL24.Semantic proximity Read ↗

Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.