Article
The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations.
Scientific reports - 26 Oct 2024
Yi Ming, Soppet Daniel, McCormick Frank, Nissley Dwight V
Abstract excerpt
In cancer research, RAS biology has been focused on only a handful of tumor types. While RAS genes have long been suspected as common contributors to a wide spectrum of cancer types, robust evidence is required to firmly establish their critical oncogenic significance. We present a data mining study using DepMap genome-wide CRISPR screening data, which provide substantial evidence to support the prominent...
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