Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.

doi:10.1093/eurheartj/ehz384

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.

European heart journal - 1 Nov 2019

Hall Kathryn T, Kessler Thorsten, Buring Julie E, Passow Dani, Sesso Howard D, Zee Robert Y L, Ridker Paul M, Chasman Daniel I, Schunkert Heribert

Abstract excerpt

AIMS: Efficacy of aspirin in primary prevention of cardiovascular disease (CVD) may be influenced by a common allele in guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk. METHODS AND RESULTS: We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele benefited from aspirin in two long-term, randomized placebo-controlled trials of aspirin in primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Aspirin

Share to Cardiovascular Diseases

Share to Coronary Artery Disease

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Primary Prevention

Source

Open in PubMed Open full text

Identifiers

PMID: 31228190
DOI: 10.1093/eurheartj/ehz384
PMCID: PMC6933533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.PMID 31228190Read ↗

The Impact of Single Nucleotide Polymorphisms and Other Mechanisms on Aspirin Resistance.Semantic proximity Read ↗

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus.Semantic proximity Read ↗

Triglyceride Polygenic Score Identifies Differential Bleeding and Cardiovascular Risk with Aspirin in Primary PreventionSemantic proximity Read ↗

Polygenic risk, aspirin, and primary prevention of coronary artery disease.Semantic proximity Read ↗

Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.Semantic proximity Read ↗

Genetic alterations in the NO-cGMP pathway and cardiovascular risk.Semantic proximity Read ↗

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.Semantic proximity Read ↗

Frequency of Genetic Polymorphisms of COX1 , GPIIIa and P2Y1 in a Chinese Population and Association with Attenuated Response to AspirinSemantic proximity Read ↗

Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use.Semantic proximity Read ↗

Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.Semantic proximity Read ↗

Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants.Semantic proximity Read ↗

Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.