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Article

An Optimized CRISPR/Cas12a Assay to Facilitate the BRAF V600E Mutation Detection.

Journal of clinical laboratory analysis - 1 Nov 2024

Etemadzadeh Azadeh, Salehipour Pouya, Motlagh Fatemeh Movahedi, Khalifeh Masoomeh, Asadbeigi Adnan, Tabrizi Mina, Shirkouhi Reza, Modarressi Mohammad Hossein

Abstract excerpt

BACKGROUND: Accurate detection of the BRAF V600E (1799T > A) mutation status can significantly contribute to selecting an optimal therapeutic strategy for diverse cancer types. CRISPR-based diagnostic platforms exhibit simple programming, cost-effectiveness, high sensitivity, and high specificity...

Topics

Proto-Oncogene Proteins B-raf
Humans
CRISPR-Cas Systems
Mutation
DNA Mutational Analysis
Limit of Detection
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39445676
DOI: 10.1002/jcla.25101
PMCID: PMC11555610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-39445676-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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