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Article

An Optimized CRISPR/Cas12a Assay to Facilitate the BRAF V600E Mutation Detection.

Journal of clinical laboratory analysis - 1 Nov 2024

Etemadzadeh Azadeh, Salehipour Pouya, Motlagh Fatemeh Movahedi, Khalifeh Masoomeh, Asadbeigi Adnan, Tabrizi Mina, Shirkouhi Reza, Modarressi Mohammad Hossein

Abstract excerpt

BACKGROUND: Accurate detection of the BRAF V600E (1799T > A) mutation status can significantly contribute to selecting an optimal therapeutic strategy for diverse cancer types. CRISPR-based diagnostic platforms exhibit simple programming, cost-effectiveness, high sensitivity, and high specificity in detecting target sequences. The goal of this study is to develop a simple BRAF V600E mutation detection method....

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Identifiers

PMID: 39445676
DOI: 10.1002/jcla.25101
PMCID: PMC11555610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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