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Article

TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes.

BMC bioinformatics - 28 Apr 2022

Liu Meiling, Goo Juna, Liu Yang, Sun Wei, Wu Michael C, Hsu Li, He Qianchuan

Abstract excerpt

BACKGROUND: T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level. The analysis of the TCR repertoire with respect to clinical phenotypes can yield novel insights into the etiology and progression of immune-mediated diseases. However, methods for...

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PMID: 35484495
DOI: 10.1186/s12859-022-04690-2
PMCID: PMC9052542

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