The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.

doi:10.1038/s41598-024-76245-9

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The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.

Scientific reports - 19 Oct 2024

Belbellaj Wiame, Lona-Durazo Frida, Bodano Cinzia, Busseuil David, Cyr Marie-Christyne, Fiorillo Edoardo, Mulas Antonella, Provost Sylvie, Steri Maristella, Tanaka Toshiko, Vanderwerff Brett, Wang Jiongming, Byrne Ross P, Cucca Francesco, Dubé Marie-Pierre, Ferrucci Luigi, McLaughlin Russell L, Tardif Jean-Claude, Zawistowski Matthew, Gagliano Taliun Sarah A

Abstract excerpt

Iron is an essential mineral that supports numerous biological functions. Studies have reported associations between iron dysregulation and certain cardiovascular and neurodegenerative diseases, but the direction of influence is not clear. Our goal was to use computational approaches to better understand the role of genetically predicted iron levels on disease risk. We meta-analyzed genome-wide association study...

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PMID: 39427026
DOI: 10.1038/s41598-024-76245-9
PMCID: PMC11490554

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