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Article

Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.

Nature communications - 2 Jul 2024

Gong Weikang, Fu Yan, Wu Bang-Sheng, Du Jingnan, Yang Liu, Zhang Ya-Ru, Chen Shi-Dong, Kang JuJiao, Mao Ying, Dong Qiang, Tan Lan, Feng Jianfeng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide association analysis of brain iron, measured by quantitative susceptibility mapping technique, across 26 brain regions among 26,789 UK Biobank participants. We find 36 genes linked to brain iron, with 29 not being...

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Identifiers

PMID: 38956042
DOI: 10.1038/s41467-024-49702-2
PMCID: PMC11219919

Genes

FTH1
GFAP
KCNA10
MLX
STAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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