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Article

Hemochromatosis neural archetype reveals iron disruption in motor circuits.

Science advances - 22 Nov 2024

Loughnan Robert, Ahern Jonathan, Boyle Mary, Jernigan Terry L, Hagler Donald J, Iversen John R, Frei Oleksandr, Smith Diana M, Andreassen Ole, Zaitlen Noah, Sugrue Leo, Thompson Wesley K, Dale Anders, Schork Andrew J, Fan Chun Chieh

Abstract excerpt

Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson's disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear. We generated scores based on the archetypal brain iron accumulation observed in magnetic resonance imaging scans of...

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Identifiers

PMID: 39576859
DOI: 10.1126/sciadv.adp4431
PMCID: PMC11584016

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