Article

Predictors of brain iron deposition in dementia and Parkinson’s disease-associated subcortical regions: genetic and observational analysis in UK Biobank

2025-02-12

Abstract excerpt

<h4>Background</h4> Brain iron in specific subcortical regions increases risk of dementia and Parkinson’s Disease (PD). Genetic and environmental factors affect iron deposition, but the underlying mechanisms are unclear. <h4>Objective</h4> Identify risk factors and diseases associated with brain iron, and assess causality using genetics. <h4>Methods</h4> 41,581 UK Biobank participants had MRI-estimated brain iron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5415873f-51f6-530f-9779-a3874deff69c
DOI: 10.1101/2025.02.11.25321877

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predictors of brain iron deposition in dementia and Parkinson’s disease-associated subcortical regions: genetic and observational analysis in UK BiobankDOI 10.1101/2025.02.11.25321877Read

Dietary Factors Affect Brain Iron Accumulation and Parkinson’s Disease RiskSemantic proximity Read

Iron and risk of dementia: Mendelian randomisation analysis in UK BiobankSemantic proximity Read

The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.Semantic proximity Read

Anemia, blood cell indices, genetic correlations, and brain structures: A comprehensive analysis of roles in Parkinson's disease risk.Semantic proximity Read

Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.Semantic proximity Read

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.Semantic proximity Read

Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization studySemantic proximity Read

Genetic impacts on nigral iron deposition in Parkinson's disease: A preliminary quantitative susceptibility mapping study.Semantic proximity Read

Association of Gout with Brain Reserve and Vulnerability to Neurodegenerative DiseaseSemantic proximity Read

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analysesSemantic proximity Read

Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.Semantic proximity Read

Exploring the Genetic and Genomic Connection Underlying Neurodegeneration with Brain Iron Accumulation and the Risk for Parkinson’s DiseaseSemantic proximity Read