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Genetically predicted iron status and cardiovascular function and structure: a Mendelian randomization study.

European journal of preventive cardiology - 18 Feb 2026

Quezada-Pinedo Hugo G, Cajachagua-Torres Kim N, Ahanchi Noushin Sadat, Khatami Farnaz, Muka Taulant, Huicho Luis, Kavousi Maryam, Eisenga Michele F, Trajanoska Katerina

Abstract excerpt

AIMS: Iron levels imbalances are linked to cardiovascular outcomes. We aimed to assess the association between genetically predicted lifelong higher iron levels and cardiovascular outcomes, employing a two-sample Mendelian randomization (MR) approach to account for confounding biases. METHODS AND RESULTS: We used a study involving 257 953 subjects across six cohort studies that identified genetic variants...

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Cardiovascular Diseases
Ferritins
Hemochromatosis Protein
Iron
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ventricular Function, Left

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PMID: 40794601
DOI: 10.1093/eurjpc/zwaf498

Genes

HFE
TF
TFR2
TMPRSS6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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