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Iron and risk of dementia: Mendelian randomisation analysis in UK Biobank

8 Jan 2024

Abstract excerpt

BACKGROUND: Brain iron deposition is common in dementia, but whether serum iron is a causal risk factor is unknown. We aimed to determine whether genetic predisposition to higher serum iron status biomarkers increased risk of dementia and atrophy of grey matter. METHODS: We analysed UK Biobank participants clustered into European (N=451284), African (N=7477) and South Asian (N=9570) groups by genetic similarity...

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PMID: 38191510
DOI: 10.1136/jmg-2023-109295

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