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Article

Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study.

Journal of the American Heart Association - 4 Jun 2024

Barad Alexa, Clark Andrew G, Pressman Eva K, O'Brien Kimberly O

Abstract excerpt

BACKGROUND: Mendelian randomization (MR) studies suggest a causal effect of iron status on cardiovascular disease (CVD) risk, but it is unknown if these associations are confounded by pleiotropic effects of the instrumental variables on CVD risk factors. We aimed to investigate the effect of iron status on CVD risk controlling for CVD risk factors. METHODS AND RESULTS: Iron biomarker instrumental variables (total...

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Identifiers

PMID: 38818967
DOI: 10.1161/JAHA.124.034991
PMCID: PMC11255641

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