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Article

Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation.

Journal of translational medicine - 15 Oct 2024

Grisolia Piera, Tufano Rossella, Iannarone Clara, De Falco Antonio, Carlino Francesca, Graziano Cinzia, Addeo Raffaele, Scrima Marianna, Caraglia Francesco, Ceccarelli Anna, Nuzzo Pier Vitale, Cossu Alessia Maria, Forte Stefano, Giuffrida Raffaella, Orditura Michele, Caraglia Michele, Ceccarelli Michele

Abstract excerpt

BACKGROUND: Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its different subtypes. We investigated whether plasma cfDNA methylation, using cell-free Methylated DNA Immunoprecipitation and High-Throughput Sequencing (cfMeDIP-seq), may be informative in characterizing breast cancer in patients with BRCA1/2 germline mutations for...

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Identifiers

PMID: 39407254
DOI: 10.1186/s12967-024-05734-2
PMCID: PMC11476115

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BRCA1
BRCA2

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