Article
Circulating breast-derived DNA allows universal detection and monitoring of localized breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2020
Moss J, Zick A, Grinshpun A, Carmon E, Maoz M, Ochana B L, Abraham O, Arieli O, Germansky L, Meir K, Glaser B, Shemer R, Uziely B, Dor Y
Abstract excerpt
BACKGROUND: Tumor-derived circulating cell-free DNA (cfDNA) is present in the plasma of individuals with cancer. Assays aimed at detecting common cancer mutations in cfDNA are being developed for the detection of several cancer types. In breast cancer, however, such assays have failed to detect the disease at a sensitivity relevant for clinical use, in part due to the absence of multiple common mutations that can...
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