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Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification

7 Apr 2018

Abstract excerpt

Background: Targeted methylation sequencing of plasma cell-free DNA (cfDNA) has a potential to expand liquid biopsies to patients with tumors without detectable oncogenic alterations, which can be potentially useful in early diagnosis. Patients and methods: We developed a comprehensive methylation sequencing assay targeting 9223 CpG sites consistently hypermethylated according to The Cancer Genome Atlas. Next, we...

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PMID: 29635542
DOI: 10.1093/annonc/mdy119

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