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Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer

16 Jun 2025

Abstract excerpt

BACKGROUND: Plasma cell-free DNA (cfDNA) methylation is emerging as a non-invasive marker for various cancers. We aimed to identify specific methylation markers for diagnosis, differentiation from benign tumors, and prognosis of breast cancer (BC), which are essential for clinical decision-making yet seldom examined together. METHODS: BC-specific methylation markers were identified using an in-house 850K dataset...

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PMID: 40524177
DOI: 10.1186/s13058-025-02066-x

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