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Multimodal analysis of cell-free DNA enhances differentiation of early-stage breast cancer from benign lesions and healthy individuals

19 Aug 2025

Abstract excerpt

BACKGROUND: Breast cancer (BC) remains the second leading cause of cancer-related mortality among women worldwide. Liquid biopsy based on circulating tumor DNA (ctDNA) offers a promising noninvasive approach for early detection; however, differentiating malignant tumors from benign abnormalities remains a significant challenge. RESULTS: Here, we developed a multimodal approach to analyze cfDNA methylation and...

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PMID: 40830871
DOI: 10.1186/s12915-025-02371-z

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