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Detection of ovarian cancer using plasma cell-free DNA methylomes

9 Jun 2022

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the use of cell-free DNA (cfDNA) methylomes to detect ovarian cancer, especially the early-stage OC. EXPERIMENTAL DESIGN: Plasma from 74 epithelial ovarian cancer patients, 86 healthy volunteers, and...

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PMID: 35681212
DOI: 10.1186/s13148-022-01285-9

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