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Article

Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci.

Antimicrobial agents and chemotherapy - 1 Jan 2013

Davlieva Milya, Zhang Wanna, Arias Cesar A, Shamoo Yousif

Abstract excerpt

Daptomycin (DAP) resistance in enterococci has been linked to mutations in genes that alter the cell envelope stress response (CESR) (liaFSR) and changes in enzymes that directly affect phospholipid homeostasis, and these changes may alter membrane composition, such as that of cardiolipin synthase (Cls). While Cls substitutions are observed in response to DAP therapy, the effect of these mutations on Cls activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23114777
DOI: 10.1128/AAC.01743-12
PMCID: PMC3535954

Genes

DAP
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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