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PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells

13 Oct 2024

Abstract excerpt

BACKGROUND: The prostaglandin receptor PTGER4 facilitates homeostasis in the gut. Previous reports indicate that goblet cells, marked by SPINK4 expression, might be affected by PTGER4 activity. Current evidence suggests that prostaglandin E2 (PGE2) produced by mesenchymal stromal cells (MSC) stimulates PTGER4 in epithelial cells during inflammatory conditions. Here, we investigate the subcellular mechanisms and...

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PMID: 39396982
DOI: 10.1186/s12964-024-01879-1

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