Histone Deacetylases in the Inflamed Intestinal Epithelium—Promises of New Therapeutic Strategies

Abstract excerpt

The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often leads to inflammation because immune cells in the lamina propria come into direct contact with luminal antigens. Defects in epithelial cell function were also shown...

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