Article
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.
Science translational medicine - 6 Jun 2018
Azouz Nurit P, Ynga-Durand Mario A, Caldwell Julie M, Jain Ayushi, Rochman Mark, Fischesser Demetria M, Ray Leanne M, Bedard Mary C, Mingler Melissa K, Forney Carmy, Eilerman Matthew, Kuhl Jonathan T, He Hua, Biagini Myers Jocelyn M, Mukkada Vincent A, Putnam Philip E, Khurana Hershey Gurjit K, Kottyan Leah C, Wen Ting, Martin Lisa J, Rothenberg Marc E
Abstract excerpt
Loss of barrier integrity has an important role in eliciting type 2 immune responses, yet the molecular events that initiate and connect this with allergic inflammation remain unclear. We reveal an endogenous, homeostatic mechanism that controls barrier function and inflammatory responses in esophageal allergic inflammation. We show that a serine protease inhibitor, SPINK7 (serine peptidase inhibitor, kazal type...
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