Article
GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.
Cell - 20 Jan 2022
Rana Nitish, Privitera Giuseppe, Kondolf Hannah C, Bulek Katarzyna, Lechuga Susana, De Salvo Carlo, Corridoni Daniele, Antanaviciute Agne, Maywald Rebecca L, Hurtado Alexander M, Zhao Junjie, Huang Emina H, Li Xiaoxia, Chan E Ricky, Simmons Alison, Bamias Giorgos, Abbott Derek W, Heaney Jason D, Ivanov Andrei I, Pizarro Theresa T
Abstract excerpt
Gasdermins are a family of structurally related proteins originally described for their role in pyroptosis. Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is known about its functional relevance during active disease states. Herein, we report increased GSDMB in inflammatory bowel...
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