Article
Loss of PI5P4Kα Slows the Progression of a Pten Mutant Basal Cell Model of Prostate Cancer.
Molecular cancer research : MCR - 2 Jan 2025
Triscott Joanna, Lehner Marika, Benjak Andrej, Reist Matthias, Emerling Brooke M, Ng Charlotte K Y, de Brot Simone, Rubin Mark A
Abstract excerpt
Although early prostate cancer depends on the androgen receptor signaling pathway, which is predominant in luminal cells, there is much to be understood about the contribution of epithelial basal cells in cancer progression. Herein, we observe cell type-specific differences in the importance of the metabolic enzyme phosphatidylinositol 5-phosphate 4-kinase alpha (PI5P4Kα; gene name PIP4K2A) in the prostate...
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