Article

IR-B deficiency and fatty acid dysregulation accelerate prostate cancer progression via PI3K/AKT signaling

2026-02-02

Abstract excerpt

<h4>ABSTRACT</h4> The insulin receptor (IR) is markedly overexpressed in both human and mouse prostate cancer, with a significant elevation in the IR-A/IR-B ratio across patient tissues, cell lines, and Hi-Myc mouse prostates. To elucidate the role of IR-B in prostate tumorigenesis, we generated a prostate-specific IR-B knockout (KO) mouse model using Pbsn-Cre –driven recombination. Prostate-restricted loss of...

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Literature Corpus work: 3f410cda-5338-5fc1-b7c5-72730b12420a
DOI: 10.64898/2026.01.30.702723

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