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Article

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

27 Jan 2004

Abstract excerpt

PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers. This tumor suppressor is a lipid phosphatase that negatively regulates cell survival and proliferation mediated by phosphatidylinositol 3-kinase/protein kinase B signaling. Using the Cre-loxP system, we selectively inactivated Pten in murine tissues in which...

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PMID: 14747659
DOI: 10.1073/pnas.0308217100

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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenPMID 14747659Read ↗

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