Article
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.
Cancer cell - 13 Mar 2017
Blattner Mirjam, Liu Deli, Robinson Brian D, Huang Dennis, Poliakov Anton, Gao Dong, Nataraj Srilakshmi, Deonarine Lesa D, Augello Michael A, Sailer Verena, Ponnala Lalit, Ittmann Michael, Chinnaiyan Arul M, Sboner Andrea, Chen Yu, Rubin Mark A, Barbieri Christopher E
Abstract excerpt
Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer. Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis in vivo. Conditional expression of mutant SPOP in the prostate dramatically altered phenotypes in the setting of Pten loss, with early neoplastic lesions (high-grade prostatic intraepithelial neoplasia) with striking nuclear atypia and...
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