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FABP5 Inhibition against PTEN-Mutant Therapy Resistant Prostate Cancer

21 Dec 2023

Abstract excerpt

Resistance to standard of care taxane and androgen deprivation therapy (ADT) causes the vast majority of prostate cancer (PC) deaths worldwide. We have developed RapidCaP, an autochthonous genetically engineered mouse model of PC. It is driven by the loss of PTEN and p53, the most common driver events in PC patients with life-threatening diseases. As in human ADT, surgical castration of RapidCaP animals...

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PMID: 38201488
DOI: 10.3390/cancers16010060

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