Article
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.
Cancer research - 1 Jul 2005
Ma Xiaoqian, Ziel-van der Made Angelique C, Autar Binha, van der Korput Hetty A, Vermeij Marcel, van Duijn Petra, Cleutjens Kitty B, de Krijger Ronald, Krimpenfort Paul, Berns Anton, van der Kwast Theo H, Trapman Jan
Abstract excerpt
The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene. In this model, Cre recombinase was expressed under the control of the prostate-specific antigen (PSA) promoter. Conditional biallelic and monoallelic Pten knock-out mice were viable and Pten...
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