Article
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Molecular cell - 2 Nov 2017
Malek Mouhannad, Kielkowska Anna, Chessa Tamara, Anderson Karen E, Barneda David, Pir Pınar, Nakanishi Hiroki, Eguchi Satoshi, Koizumi Atsushi, Sasaki Junko, Juvin Véronique, Kiselev Vladimir Y, Niewczas Izabella, Gray Alexander, Valayer Alexandre, Spensberger Dominik, Imbert Marine, Felisbino Sergio, Habuchi Tomonori, Beinke Soren, Cosulich Sabina, Le Novère Nicolas, Sasaki Takehiko, Clark Jonathan, Hawkins Phillip T, Stephens Len R
Abstract excerpt
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2. The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN also functions as...
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