Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis.

doi:10.1158/1055-9965.EPI-24-0926

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Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Dec 2024

Hazelwood Emma, Lopez Manzano Catalina, Vincent Emma E, Albanes Demetrius, Bishop David Timothy, Le Marchand Loïc, Ulrich Cornelia M, Peters Ulrike, Murphy Gwen, Samadder Niloy Jewel, Anderson Laura, Gunter Marc J, Murphy Neil, Van Guelpen Bethany, Papadimitriou Nikos

Abstract excerpt

BACKGROUND: Epidemiological and laboratory-based studies have provided conflicting evidence for a role of ghrelin in colorectal cancer development. We conducted two-sample Mendelian randomization (MR) analyses to evaluate evidence for an association of circulating ghrelin and colorectal cancer risk overall and by sex, cancer subsite, and age at diagnosis. METHODS: Genetic instruments proxying plasma total ghrelin...

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PMID: 39361354
DOI: 10.1158/1055-9965.EPI-24-0926
PMCID: PMC11609820

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