Article
Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses.
EBioMedicine - 1 Mar 2024
Papadimitriou Nikos, Qu Conghui, Harrison Tabitha A, Bever Alaina M, Martin Richard M, Tsilidis Konstantinos K, Newcomb Polly A, Thibodeau Stephen N, Newton Christina C, Um Caroline Y, Obón-Santacana Mireia, Moreno Victor, Brenner Hermann, Mandic Marko, Chang-Claude Jenny, Hoffmeister Michael, Pellatt Andrew J, Schoen Robert E, Harlid Sophia, Ogino Shuji, Ugai Tomotaka, Buchanan Daniel D, Lynch Brigid M, Gruber Stephen B, Cao Yin, Hsu Li, Huyghe Jeroen R, Lin Yi, Steinfelder Robert S, Sun Wei, Van Guelpen Bethany, Zaidi Syed H, Toland Amanda E, Berndt Sonja I, Huang Wen-Yi, Aglago Elom K, Drew David A, French Amy J, Georgeson Peter, Giannakis Marios, Hullar Meredith, Nowak Johnathan A, Thomas Claire E, Le Marchand Loic, Cheng Iona, Gallinger Steven, Jenkins Mark A, Gunter Marc J, Campbell Peter T, Peters Ulrike, Song Mingyang, Phipps Amanda I, Murphy Neil
Abstract excerpt
BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and...
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