Article
Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2021
Hua Xinwei, Dai James Y, Lindström Sara, Harrison Tabitha A, Lin Yi, Alberts Steven R, Alwers Elizabeth, Berndt Sonja I, Brenner Hermann, Buchanan Daniel D, Campbell Peter T, Casey Graham, Chang-Claude Jenny, Gallinger Steven, Giles Graham G, Goldberg Richard M, Gunter Marc J, Hoffmeister Michael, Jenkins Mark A, Joshi Amit D, Ma Wenjie, Milne Roger L, Murphy Neil, Pai Rish K, Sakoda Lori C, Schoen Robert E, Shi Qian, Slattery Martha L, Song Mingyang, White Emily, Marchand Loic Le, Chan Andrew T, Peters Ulrike, Newcomb Polly A
Abstract excerpt
BACKGROUND: A positive association between circulating C-reactive protein (CRP) and colorectal cancer survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically predicted CRP concentrations and colorectal cancer-specific survival. METHODS: We used individual-level...
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