Article
Mendelian Randomization Study: The Association Between Metabolic Pathways and Colorectal Cancer Risk
23 Jul 2020
Abstract excerpt
Background: The roles of obesity-related biomarkers and their molecular pathways in the development of postmenopausal colorectal cancer (CRC) have been inconclusive. We examined insulin resistance (IR) as a major hormonal pathway mediating the association between obesity and CRC risk in a Mendelian randomization (MR) framework. Methods: We performed MR analysis using individual-level data of 11,078 non-Hispanic...
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