Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.

doi:10.1186/s12916-022-02702-9

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Article

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.

BMC medicine - 4 Jan 2023

Papadimitriou Nikos, Bull Caroline J, Jenab Mazda, Hughes David J, Bell Joshua A, Sanderson Eleanor, Timpson Nicholas J, Smith George Davey, Albanes Demetrius, Campbell Peter T, Küry Sébastien, Le Marchand Loic, Ulrich Cornelia M, Visvanathan Kala, Figueiredo Jane C, Newcomb Polly A, Pai Rish K, Peters Ulrike, Tsilidis Kostas K, Boer Jolanda M A, Vincent Emma E, Mariosa Daniela, Gunter Marc J, Richardson Tom G, Murphy Neil

Abstract excerpt

BACKGROUND: Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colorectal cancer risk. METHODS: We conducted Mendelian randomization (MR) analyses to investigate potential causal relationships between self-perceived body size (thinner, plumper, or about average)...

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PMID: 36600297
DOI: 10.1186/s12916-022-02702-9
PMCID: PMC9814460

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