Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.

doi:10.1186/s12916-023-03104-1

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Article

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.

BMC medicine - 13 Oct 2023

Nimptsch Katharina, Aleksandrova Krasimira, Pham Thu Thi, Papadimitriou Nikos, Janke Jürgen, Christakoudi Sofia, Heath Alicia, Olsen Anja, Tjønneland Anne, Schulze Matthias B, Katzke Verena, Kaaks Rudolf, van Guelpen Bethany, Harbs Justin, Palli Domenico, Macciotta Alessandra, Pasanisi Fabrizio, Yohar Sandra Milena Colorado, Guevara Marcela, Amiano Pilar, Grioni Sara, Jakszyn Paula Gabriela, Figueiredo Jane C, Samadder N Jewel, Li Christopher I, Moreno Victor, Potter John D, Schoen Robert E, Um Caroline Y, Weiderpass Elisabete, Jenab Mazda, Gunter Marc J, Pischon Tobias

Abstract excerpt

BACKGROUND: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization...

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PMID: 37833736
DOI: 10.1186/s12916-023-03104-1
PMCID: PMC10576353

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