Article
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
BMC medicine - 17 Dec 2020
Bull Caroline J, Bell Joshua A, Murphy Neil, Sanderson Eleanor, Davey Smith George, Timpson Nicholas J, Banbury Barbara L, Albanes Demetrius, Berndt Sonja I, Bézieau Stéphane, Bishop D Timothy, Brenner Hermann, Buchanan Daniel D, Burnett-Hartman Andrea, Casey Graham, Castellví-Bel Sergi, Chan Andrew T, Chang-Claude Jenny, Cross Amanda J, de la Chapelle Albert, Figueiredo Jane C, Gallinger Steven J, Gapstur Susan M, Giles Graham G, Gruber Stephen B, Gsur Andrea, Hampe Jochen, Hampel Heather, Harrison Tabitha A, Hoffmeister Michael, Hsu Li, Huang Wen-Yi, Huyghe Jeroen R, Jenkins Mark A, Joshu Corinne E, Keku Temitope O, Kühn Tilman, Kweon Sun-Seog, Le Marchand Loic, Li Christopher I, Li Li, Lindblom Annika, Martín Vicente, May Anne M, Milne Roger L, Moreno Victor, Newcomb Polly A, Offit Kenneth, Ogino Shuji, Phipps Amanda I, Platz Elizabeth A, Potter John D, Qu Conghui, Quirós J Ramón, Rennert Gad, Riboli Elio, Sakoda Lori C, Schafmayer Clemens, Schoen Robert E, Slattery Martha L, Tangen Catherine M, Tsilidis Kostas K, Ulrich Cornelia M, van Duijnhoven Fränzel J B, van Guelpen Bethany, Visvanathan Kala, Vodicka Pavel, Vodickova Ludmila, Wang Hansong, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Campbell Peter T, Zheng Wei, Peters Ulrike, Vincent Emma E, Gunter Marc J
Abstract excerpt
BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. METHODS: We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations...
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