Article
Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.
Pediatric obesity - 1 Jan 2025
Papadimitriou Nikos, Murphy Neil, Jenab Mazda, Chen Zhishan, Brenner Hermann, Kweon Sun-Seog, Le Marchand Loic, Moreno Victor, Platz Elizabeth A, van Duijnhoven Fränzel J B, Cheng Iona, Pai Rish K, Phipps Amanda I, Peters Ulrike, Zheng Wei, Hughes David J
Abstract excerpt
BACKGROUND: Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early...
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